| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 49356 | Catalysis Communications | 2015 | 5 Pages |
•Suzuki–Miyaura reaction of potassium aryltrifluoroborates in pure water•(i-Pr)2NH promotes the cross-coupling efficiently.•This protocol provides a gram scale preparation of 2-cyano-4′-methylbiphenyl.•The products could be isolated by simple filtration and recrystallization.
An efficient and environment-friendly protocol has been developed for the palladium-catalyzed Suzuki–Miyaura reaction of potassium aryltrifluoroborates with (hetero)aryl halides in water without any additive. This method allows the preparation of a variety of biaryls and heterobiaryls in excellent yields. In addition, the cross-coupling product can be isolated in good yields and high purity by simple filtration and recrystallization as the reaction was performed on gram scale.
Graphical abstractAn efficient and environment-friendly protocol has been developed for the palladium-catalyzed Suzuki–Miyaura reaction of potassium aryltrifluoroborates and (hetero)aryl halides in water without any additives.Figure optionsDownload full-size imageDownload as PowerPoint slide
