Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4979932 | Journal of Hazardous Materials | 2017 | 38 Pages |
Abstract
First, linearity of the Orbitrap response showed to be matrix dependent in a counter intuitive way: stronger deviations from linearity were observed for pure solvent standards than for complex matrices like wastewater. Second, detection limits risk to be overestimated for ubiquitously present compounds for which true blank matrix samples are hard to find, leading to false negative findings. A novel and easy applicable methodology is presented to allow a better estimation of detection limits using the response of the natural isotopes. Third, a statistical methodology to estimate the measurement precision of the analyte concentration using basic validation parameters is developed specifically for the context of multi-residue quantification.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Health and Safety
Authors
Leendert Vergeynst, Kenneth K'oreje, Patrick De Wispelaere, Lies Harinck, Herman Van Langenhove, Kristof Demeestere,