Copper iodide nanoparticles on poly(4-vinyl pyridine): A new and efficient catalyst for multicomponent click synthesis of 1,4-disubstituted-1,2,3-triazoles in water

Polymer supported nanoparticles of copper(I) iodide is reported as a new, efficient and recyclable catalyst for the regioselective multicomponent synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from α-halo ketones, sodium azide and terminal alkynes in water. This catalyst can be recovered by simple filtration and recycled up to 8 consecutive runs without losing its efficiency.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Click synthesis of triazole derivatives ► High product yields with short reaction times ► Heterogeneous catalysis and recyclability of the catalyst