Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5002942 | IFAC-PapersOnLine | 2016 | 6 Pages |
Abstract
We consider a realistic model of the synthetic gene circuit combining cell-to-cell communication system via quorum sensing, and a synthetic repressible promoter implementing intracellular negative feedback control. The circuit has been shown to increase robustness with respect to both extrinsic and intrinsic noise elsewhere. As a first step towards an analytic analysis, in this paper we use contraction theory to perform a stability analysis. From it, we infer the components of the circuit most affecting the rate of contractivity, using biologically sensible values of the circuit parameters.
Related Topics
Physical Sciences and Engineering
Engineering
Computational Mechanics
Authors
E. Picó-Marco, Y. Boada, J. Picó, A. Vignoni,