Article ID Journal Published Year Pages File Type
5002942 IFAC-PapersOnLine 2016 6 Pages PDF
Abstract
We consider a realistic model of the synthetic gene circuit combining cell-to-cell communication system via quorum sensing, and a synthetic repressible promoter implementing intracellular negative feedback control. The circuit has been shown to increase robustness with respect to both extrinsic and intrinsic noise elsewhere. As a first step towards an analytic analysis, in this paper we use contraction theory to perform a stability analysis. From it, we infer the components of the circuit most affecting the rate of contractivity, using biologically sensible values of the circuit parameters.
Related Topics
Physical Sciences and Engineering Engineering Computational Mechanics
Authors
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