| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 50061 | Catalysis Communications | 2015 | 4 Pages |
•NaI-mediated α-oxybenzoylation of dimethyl malonate with carboxylic acids was developed.•Two different reaction routes controlled by temperature were observed.•Two types of coupling products were isolated in good to high yields.•The reaction mechanisms were proposed based on the results observed.
A NaI-mediated α-functionalization of dimethyl malonate and its derivatives with carboxylic acids has been developed. Two different reaction routes based on the same substrates and reaction conditions by simply altering the reaction temperature have been observed, which led to the synthesis of two types of products in good to high yields. The scope of substrates was investigated for both types of reactions, respectively, and possible reaction mechanisms were suggested.
Graphical abstractA NaI-mediated α-functionalization of dimethyl malonate and its derivatives with carboxylic acids has been developed. Two different reaction routes based on the same substrates and reaction conditions by simply altering the reaction temperature have been observed, which led to the synthesis of two types of products in good to high yields. The scope of substrates was investigated for both types of reactions, respectively, and possible reaction mechanisms were suggested.Figure optionsDownload full-size imageDownload as PowerPoint slide
