| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 50109 | Catalysis Communications | 2016 | 5 Pages |
Abstract
•A lipase-catalyzed, cascade kinetic resolution protocol has been established.•Enantiopure 3-phenyloxazolidin-2-one derivatives have been synthesized.•Candida antarctica Lipase B showed high catalytic activity and stereoselectivity.
A lipase-catalyzed, cascade kinetic resolution protocol has been established for the synthesis of 3-phenyloxazolidin-2-one derivatives with up to excellent enantioselectivities (95% ee). Candida antarctica lipase B showed high catalytic activity and stereoselectivity in sequential O- and N-alkoxycarbonylation processes.
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Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Yang Zhang, Yan Zhang, Sheng Xie, Mingdi Yan, Olof Ramström,