CTAB immobilized carbon paste electrode for the determination of mesalazine: A cyclic voltammetric method

The electrochemical behavior of mesalazine (MSZ) was investigated at CTAB immobilized CPE in 0.2 M PBS of pH 7.4 by cyclic voltammetric technique. The modified electrode was exhibited a good electrochemical activity towards the oxidation of mesalazine, which results in the noticeable improvement of the peak currents and feasible oxidation as compared to the bare carbon paste electrode. Under optimal experimental conditions the electrochemical response to MSZ was linear in the concentration range from 60 μM to 140 μM with a detection limit of 1.9 nM by cyclic voltammetric technique. The sensitivity, long-term stability, reproducibility was shown by the modified electrode. Overall, the proposed method was successfully applied to determine MSZ in pharmaceutical samples and satisfactory results were obtained.