Attachment of Primary Mouse Astroglial Cells on Neural Implant Surfaces

In vitro micro- and nanofabricated test chips were used to investigate mouse primary cortical astroglial cell reactions to different surfaces of a multichannel neural microelectrode implant. The following surface types were fabricated by MEMS technology and characterized by scanning electron microscopy: poly-Si, Pt, nanostructured Si and nanostructured Pt. Survival of primary cortical mouse astroglial cells was analysed by fluorescent microscopy 24 hours after seeding. Our results show that the nanostructured surfaces are not toxic to the primary mouse astroglial cells.