Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5030823 | Biosensors and Bioelectronics | 2018 | 9 Pages |
â¢Cooperative host-guest interactions driven rapid on field detection of Hg2+.â¢A reliable visible, fluorescence and SERS-based ultrasensitive and selective Hg2+ marker.â¢Development of HPH functionalized Au-MNM Based ultrasensitive SERS Substrate.â¢Detection limit of 60Ã10-18 M (60 attomolar or 0.01 ppq) is the best ever reported in water.
The development of reliable and ultrasensitive detection marker for mercury ions (Hg2+) in drinking water is of great interest for toxicology assessment, environmental protection and human health. Although many Hg2+ detection methods have been developed, only few offer sensitivities below 1Â pM. Herein, we describe a simple histidine (H) conjugated perylene diimide (PDI) bolaamphiphile (HPH) as a dual-responsive optical marker to develop highly selective and sensitive probe as visible (sol-to-gel transformation), fluorescence and SERS-based Hg2+sensor platform in the water. Remarkably, HPH as a SERS marker supported on Au deposited monodispersed nanospheres monolayers (Au-MNM) of polystyrene offers an unprecedented selectivity and the best ever reported detection limit (LOD) of 60 attomolar (aM, 0.01 parts-per-quadrillion (ppq)) for Hg2+ in water. This is ten orders of magnitude lower than the United States Environmental Protection Agency (USEPA) tolerance limit of Hg2+ in drinking water (10Â nM, 2 ppb). This simple and effective design principle of host-guest interactions driven fluorescence and SERS-based detection may inspire the future molecular engineering strategies for the development of ultrasensitive toxic analyte sensor platforms.
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