Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5030844 | Biosensors and Bioelectronics | 2017 | 10 Pages |
Abstract
In this work, we investigate the detection sensitivity of surface plasmon resonance (SPR) biosensors by engineering spatial distribution of electromagnetic near-fields for colocalization with molecular distribution. The light-matter colocalization was based on plasmonic nanolithography, the concept of which was confirmed by detecting streptavidin biotin interactions on triangular nanoaperture arrays after the structure of the aperture arrays was optimized for colocalization efficiency. The colocalization was shown to amplify optical signature significantly and thereby to achieve detection on the order of 100 streptavidin molecules with a binding capacity below 1Â fg/mm2, an enhancement by more than three orders of magnitude over conventional SPR detection.
Related Topics
Physical Sciences and Engineering
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Analytical Chemistry
Authors
Kiheung Kim, Wonju Lee, Kyungwha Chung, Hongki Lee, Taehwang Son, Youngjin Oh, Yun-Feng Xiao, Dong Ha Kim, Donghyun Kim,