Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5030851 | Biosensors and Bioelectronics | 2017 | 27 Pages |
Abstract
Herein, bimetallic alloyed AuAg hollow nanocrystals (AuAg HNCs) were prepared by a simple one-pot aqueous method using polycytidysic acid (PCA) as the green growth-directing agent. The novel immunosensor for carbohydrate antigen 199 (CA199) was further constructed based on the enhanced catalytic currents of oxygen reduction reaction (ORR) by AuAg HNCs. By virtue of the good biocompatibility and catalytic activity of AuAg HNCs, the immunosensor exhibited superior analytical performance for the assay of CA199 under the optimal experimental conditions, the ORR signals linearly decreased with the increased CA199 concentrations in the range of 1 ~Â 30Â UÂ mL-1, with the low detection limit of 0.228Â UÂ mL-1, improved stability, reproducibility and selectivity.
Related Topics
Physical Sciences and Engineering
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Authors
Rui Wang, Jiu-Ju Feng, Wei-Dong Liu, Liu-Ying Jiang, Ai-Jun Wang,