MEG Based Functional Connectivity: Application of ICA to Alleviate Signal Leakage

- Inverse solution for reconstruction of source MEG time series cause signal leakage.
- Signal leakage may cause spurious functional connectivity (FC).
- Evaluated ICA based orthogonalization approach to suppress such signal leakage.
- Correlation between two band limited time series was used as a FC measure.
- Prior ICA application efficiently suppressed the spurious FC due to signal leakage.