Original ArticleDetermination of Dichlorvos Effect on Uterine Contractility Using Wavelet Transform

•Effects of different doses of dichlorvos on isolated uterus muscle contractions are evaluated.•Wavelet scalogram analysis is preferred in the study because of its simultaneous time, frequency and energy screening capability.•Obtained results show that:∘Increasing doses of dichlorvos decreases the energy and frequency of contractions,∘The results showed that 50 and 100 μM dichlorvos concentrations decrease the energy of contractions significantly.•The study is important in that it shows toxic effects of DDVP on uterus which is responsible for reproductive function of mammalians and that it draws attention to an important public health problem. Furthermore, this is the first study showing that the wavelet transform can be readily utilized to determine the effects of insecticides and similar chemicals on the uterus spontaneous activity.

Purpose: The use of organic synthetic pesticides has increased heavily in recent years and organophosphate insecticides constitute 20-38% of the total pesticides used worldwide. Dichlorvos, an organic phosphate insecticide, is widely used for the control of the agricultural, industrial and domestic pest in most of the agricultural countries like Turkey and it is known that many chemical toxins are capable of producing changes in uterine contractions. In this study, the effects of different doses of dichlorvos on isolated uterus muscle contractions are evaluated.Methods: Wavelet scalogram analysis is preferred in the study because of its simultaneous time, frequency and energy screening capability.Results: Obtained results show that 50 μM and 100 μM doses of DDVP significantly decreased the energy of contractions.Conclusions: The study is important in that it shows toxic effects of DDVP on uterus which is responsible for reproductive function of mammalians and that it draws attention to an important public health problem. Furthermore, this is the first study showing that the wavelet transform can be readily utilized to determine the effects of insecticides and similar chemicals on the uterus spontaneous activity.

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