Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5032125 | Journal of Biomechanics | 2017 | 6 Pages |
Abstract
Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.
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Physical Sciences and Engineering
Engineering
Biomedical Engineering
Authors
Marvin J. Slepian, Jawaad Sheriff, Marcus Hutchinson, Phat Tran, Naing Bajaj, Joe G.N. Garcia, S. Scott Saavedra, Danny Bluestein,