A new silica based substituted piperidine derivative catalyzed expeditious room temperature synthesis of homo and hetero bis-Knoevenagel condensation products

A new silica based piperidine derivative has been designed, synthesized and characterized by solid state carbon 13 CP MAS NMR, BET surface area analysis, IR, TGA studies, elemental analysis and pH experiment. This has been efficiently utilized as a recyclable catalyst for both homo and hetero bis-Knoevenagel condensation products in aqueous-ethanol. This is the first report of the synthesis of hetero bis-Knoevenagel condensation products by our designed catalyst.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideResearch Highlights► Synthesis and characterization of heterogeneous silica based piperidine catalyst. ► Utilization for the synthesis of bis-homo and bis-hetero Knoevenagel products. ► Recyclability of the solid catalyst at least upto eight cycles. ► Sequential addition of the active methylene compounds afforded bis-hetero products.