Characterization of micro-resonator based on enhanced metal insulator semiconductor capacitor for glucose recognition

•The characterization of the micro-resonator incorporating MIS capacitor for glucose detection implemented on the standard solution of d-glucose and the serum.•Discrepancy in complex permittivity was implemented for variation of the MIS capacitance which indeed results for the level of glucose concentration detection.•Minimum detectable glucose level of 7.45 mg/dl with good linearity among the concentrations.•The MIS based capacitive sensing has been validated with the best resolution of 112.38 × 10−3 pF/mg/dl.

We present a concept for the characterization of micro-fabricated based resonator incorporating air-bridge metal-insulator-semiconductor (MIS) capacitor to continuously monitor an individual's state of glucose levels based on frequency variation. The investigation revealed that, the micro-resonator based on MIS capacitor holds considerable promise for implementation and recognition as a glucose sensor for human serum. The discrepancy in complex permittivity as a result of enhanced capacitor was achieved for the detection and determination of random glucose concentration levels using a unique variation of capacitor that indeed results in an adequate variation of the resonance frequency. Moreover, the design and development of micro-resonator with enhanced MIS capacitor generate a resolution of 112.38 × 10−3 pF/mg/dl, minimum detectable glucose level of 7.45 mg/dl, and a limit of quantification of 22.58 mg/dl. Additionally, this unique approach offers long-term reliability for mediator-free glucose sensing with a relative standard deviation of less than 0.5%.