| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 50329 | Catalysis Communications | 2013 | 4 Pages |
A fast condensation of cyclohexanone with 2-aminobenzonitrile catalysed by N-heterocyclic carbene 1,3-dipropylimidazole-2-ylidene (NHC-PPIm) at room temperature was discovered. NHC-PPIm was prepared via concentration of a 1,3-dipropylimidazolium hydroxide aqueous solution and showed excellent catalytic activity in the condensation reaction for the synthesis of quinazolinone. A possible catalytic mechanism was proposed based on the umpolung of cyclohexanone.
► Synthesis of quinazolinone via condensation of cyclohexanone with 2-aminobenzonitrile. ► An NHC was produced via concentration of a [PPIm][OH] aqueous solution. ► The NHC showed high catalytic activity in the condensation reaction. ► A possible catalytic mechanism was proposed based on the umpolung of cyclohexanone.
