Article ID Journal Published Year Pages File Type
5041328 Brain and Language 2017 6 Pages PDF
Abstract

•A left-handed woman became aphasic following right hemisphere MCA stroke.•During recovery there was a loss in RH and gain in LH ROIs supporting processing.•During recovery more ROI dynamics drove LH ROIs, and fewer drove RH ROIs.•The resultant network was more left-lateralized than that of right-handed controls.

In this paper we demonstrate the application of new effective connectivity analyses to characterize changing patterns of task-related directed interaction in large (25-55 node) cortical networks following the onset of aphasia. The subject was a left-handed woman who became aphasic following a right-hemisphere stroke. She was tested on an auditory word-picture verification task administered one and seven months after the onset of aphasia. MEG/EEG and anatomical MRI data were used to create high spatiotemporal resolution estimates of task-related cortical activity. Effective connectivity analyses of those data showed a reduction of bilateral network influences on preserved right-hemisphere structures, and an increase in intra-hemispheric left-hemisphere influences. She developed a connectivity pattern that was more left lateralized than that of right-handed control subjects. Her emergent left hemisphere network showed a combination of increased functional subdivision of perisylvian language areas and recruitment of medial structures.

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