Article ID Journal Published Year Pages File Type
5043306 Neurobiology of Learning and Memory 2017 6 Pages PDF
Abstract

•miR-335-5p down-regulation is proposed as a mechanism necessary to stabilize plasticity and spatial memory.•Down-regulation of miRNA-335-5p expression in the hippocampus is demonstrated after Morris Water maze training.•Overexpression miRNA-335-5p impairs spatial memory.•miRNA-335-5p down regulation is necessary for hippocampal LTP maintenance.

MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.

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