Stereoselective hydroxylation of ethylbenzene to (R)-1-phenylethanol using mycelia of Aspergillus niger as catalyst

The mycelia of Aspergillus niger MTCC-404 have been shown to act as a biocatalyst for the transformation of ethylbenzene to (R)-1-phenylethanol in 99% enantiomeric excess. 72% of the products are (R)-1-phenylethanol. The conversion yield is dependent on pH, temperature and mycelia concentration in suspension. A. niger MTCC-404 facilitates methylbenzene transformation to benzylalcohol, and propylbenzene to 1-phenylpropanol. Therefore, A. niger serves as a biocatalyst for hydroxylation of alkylbenzene's benzylic position.

Graphical AbstractEthylbenzene has been stereoselectively hydroxylated to (R)-1-phenylethanol using the mycelia of Aspergillus niger MTCC-404 as a biocatalyst.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch Highlights►Stereoselective hydroxylation of ethylbenzene has been achieved. ►(R)-1-phenylethanol in 99% enantiomeric execess has been prepared. ►Aspergillus niger MTCC-404 mycelia have been used as a biocatalyst. ►This mycro-organism has a potential for benzylic hydroxylation of alkylbenzenes.