Article ID Journal Published Year Pages File Type
5102451 Physica A: Statistical Mechanics and its Applications 2018 20 Pages PDF
Abstract
Cellular homoeostasis involves a continuous interaction between the cell and its microenvironment. As such, active and passive transport of ions, nutrients, molecules and water are the basis for biochemical-physical cell life. These transport phenomena change the internal and external ionic concentrations, and, as a consequence, the cell membrane's electric potential and the pH. In this paper we focus on the relationship between these ion transport-induced pH and membrane voltage changes to highlight their impact on carcinogenesis. The preliminary results suggest a critical role for Cl− in driving tumour transformation towards a more malignant phenotype.
Related Topics
Physical Sciences and Engineering Mathematics Mathematical Physics
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