Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5102451 | Physica A: Statistical Mechanics and its Applications | 2018 | 20 Pages |
Abstract
Cellular homoeostasis involves a continuous interaction between the cell and its microenvironment. As such, active and passive transport of ions, nutrients, molecules and water are the basis for biochemical-physical cell life. These transport phenomena change the internal and external ionic concentrations, and, as a consequence, the cell membrane's electric potential and the pH. In this paper we focus on the relationship between these ion transport-induced pH and membrane voltage changes to highlight their impact on carcinogenesis. The preliminary results suggest a critical role for Clâ in driving tumour transformation towards a more malignant phenotype.
Related Topics
Physical Sciences and Engineering
Mathematics
Mathematical Physics
Authors
Umberto Lucia, Giulia Grisolia, Antonio Ponzetto, Thomas S. Deisboeck,