Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
51063 | Catalysis Communications | 2010 | 5 Pages |
Abstract
Asymmetric epoxidation of 3-chloropropene can be catalyzed by chloroperoxidase (CPO) from Caldariomyces fumago to prepare (R)-epichlorohydrin (ECH) in homogenous phosphate buffer/ionic liquid mixtures using t-butyl hydroperoxide (TBHP) as O2 donor.Reaction conditions were optimized by the investigation of the choice of oxidants, the presence of ionic liquids (ILs), pH effect and CPO consumption. The best ECH yield reached 88.8% within a duration of 60 min with high enantiomeric excesses (e.e. 97.1%) at pH 5.5 and room temperature, using 1-ethyl-3-methylimidazolium [EMIM][Br] as co-solvent. The ILs with shorter carbon chain was more efficient on chiral ECH preparation.
Related Topics
Physical Sciences and Engineering
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Catalysis
Authors
Jinyue Wu, Chen Liu, Yucheng Jiang, Mancheng Hu, Shuni Li, Quanguo Zhai,