Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5124249 | Journal of Voice | 2017 | 6 Pages |
SummaryObjectiveThis study aims to investigate the correlations between serum apolipoprotein A-I (ApoA-I) and the formation of vocal cord polyps (VCPs).Study DesignThis study used the nonmatched case-control study method.MethodsThe serum total cholesterol (TC), triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, ApoA-I, apolipoprotein B (ApoB), and ApoA-I/ApoB levels of 89 VCP patients and 87 normal volunteers were compared. Additionally, such VCP-related factors as excessive vocal use, vocal abuse, smoking, drinking, and the size of VCPs were analyzed.ResultsThe two groups did not significantly differ with regard to triglyceride, low-density lipoprotein cholesterol, ApoB, and ApoA-I/ApoB levels (Pâ>â0.05), whereas they did significantly differ with regard to TC, HDL-C, and ApoA-I levels (Pâ<â0.05) according to independent t tests. Logistic regression analysis showed that excessive vocal use and vocal abuse were risk factors for VCPs (Pâ<â0.05), with odds ratio values of 5.675 and 12.781, respectively. The ApoA-I level was negatively associated with VCPs (Pâ<â0.05), with an odds ratio of 0.511; however, TC and HDL-C were not associated with the formation of VCPs (Pâ>â0.05). The size of VCPs in females was negatively correlated with the serum ApoA-I level (râ=ââ0.349, Pâ=â0.032), whereas that in males was not (Pâ>â0.05).ConclusionsAs the serum ApoA-I level was negatively correlated with the formation of VCPs, ApoA-I may reduce the risk of VCPs. These findings may facilitate the prevention and treatment of VCPs.