Gold complex-catalyzed CP bond formation by Kabachnik–Fields reactions

CP bond formation was realized through the three-component reaction of an amine, an aldehyde and a dialkylphosphite catalyzed by gold complex. The corresponding α-aminophosphonates were afforded in one-pot reaction with high yields under mild conditions.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► C–P bonds formation was realized through the reaction catalyzed by gold complex. ► Gold-bipy complex show the best catalytic activity. ► Reactions of aldehydes with aromatic amines do not show remarkable difference. ► A plausible mechanism of the reaction is proposed based on some experiments. ► Cleaner conversion, higher yields are some of the advantages of the protocol.