Trace determination of organophosphate esters in white wine, red wine, and beer samples using dispersive liquid-liquid microextraction combined with ultra-high-performance liquid chromatography-tandem mass spectrometry

•DLLME-UPLC-MS/MS was developed for the determination of OPEs from wines.•Results showed that high analytes recoveries were achieved with the proposed method.•The tested OPEs were found in the real samples with different levels.•It is promising to be used for the analysis of trace amount of OPEs in the future.

In this study, dispersive liquid-liquid microextraction coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry was developed for the analysis of five representative organophosphate esters (OPEs) in wine samples. Under optimized conditions, the proposed method resulted in good linearity (R2 > 0.9933) over the range of 0.1-100 μg L−1, with limits of detection (LODs, S/N = 3) and quantification (LOQs, S/N = 10) in the ranges of 0.48-18.8 ng L−1 and 1.58-62.5 ng L−1, respectively. Inter- and intra-assay precisions of RSD% ranged from 3.21% to 6.13% and from 1.69% to 7.63%, respectively. The spiked recoveries of target OPEs from white wine, red wine, and beer samples were in the ranges of 80-122%, 76-120%, and 76-110%, respectively, at two different concentration levels. The total concentrations of five OPEs found in white wine, red wine, and beer samples were in the ranges of 0.29-0.85 μg L−1, 1.00-3.05 μg L−1, and 0.86-1.47 μg L−1, respectively.