+Facile extraction of azide in sartan drugs using magnetized anion-exchange metal-organic frameworks prior to ion chromatography

•A type of magnetized anion-exchange metal-organic framework was synthesized.•MOF materials were used for the adsorption of azide firstly.•Combined with IC, the MSPE method offered satisfactory performance for detecting trace azide in sartan drugs.•Compared with previous methods, this approach offers ease of operation, remarkable sensitivity, satisfactory reproducibility and low cost.

Quaternary amine functionalized metal-organic framework MIL-101(Cr) (MIL-101(Cr)-NMe3) was prepared as the sorbent for the magnetic solid-phase extraction (MSPE) of azide from sartan drugs before ion chromatography determination. Magnetization of MIL-101-NMe3 were achieved concurrently by adding MIL-101-NMe3 and Fe3O4@SiO2 to the sample solution under ultrasonication. The prepared Fe3O4@SiO2/MIL-101-NMe3 gave the adsorption capacity of 37.5 mg g−1. The developed method had a detection limit of 0.24 μg L−1 and quantitation limit of 0.79 μg L−1 for azide. The relative standard deviations for the intra-day retention time and peak area were 0.52% and 0.36% (n = 5), respectively. The developed method was successfully applied for the determination of azide in sartan drugs with the recoveries from 96.5% to 100.5%.