| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5136386 | Journal of Chromatography B | 2017 | 9 Pages |
â¢Review of HPLC-MS/MS methods for quantitation of anticancer drugs in urine.â¢Includes drugs, isomers, drug metabolites and simultaneous multi-drug determinations.â¢Tabular summaries of method sample preparation, LC parameters, and MS detection modes.â¢Presents comparative overview of methods, their development, and validation protocols.â¢Discussion of future trends including UHPLC-MS/MS and simultaneous multi-drug methods.
This review describes published high performance liquid chromatography/mass spectrometry (HPLC-MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC-MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC-MS methods are presented, as well as future trends and limitations in this area of research.
