The 2nd order focusing sector field type TOF mass analyzer with an orthogonal ion acceleration for LC-IMS-MS

•The second order focusing conditions have been found for the sector field TOF mass analyzer with orthogonal acceleration.•The aberrational limit of RFW ≈ 80,000 has been found for the δE/E0 = 2.5% at OA exit and 50 μs spectra duration for m/z 1000.•It allows to achieve higher mass resolution with a high acquisition rate (up to 10-20 kHz).

Original orthogonal acceleration (OA) electrostatic sector time of flight (TOF) mass analyzer is proposed those allows the second order focusing of time of flight by initial ions position. Resolving power aberration limit exceeding 80,000 FW (full width mass peak) was shown to be obtainable for mass analyzer with the total length of flight L = 133.2 cm, the average ion energy 3700 V and the ion energy spread of 2.5% on the entrance of sector field.