Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5136789 | Journal of Chromatography B | 2017 | 15 Pages |
Abstract
Molecularly imprinted polymers (MIP) are stable polymers with molecular recognition abilities, provided by the presence of a template during their synthesis, and are excellent materials with high selectivity for sample preparation in bioanalytical methods. This short review discusses aspects of MIP preparation and its applications as a sorbent material in pharmaceutical and biomedical analysis. MIP in different extraction configurations, including classical solid-phase extraction, solid-phase microextraction, magnetic molecularly imprinted solid-phase extraction, microextraction by packed sorbent and solid-phase extraction in pipette tips, are used to illustrate the good performance of this type of sorbent for sample preparation procedures of complex matrices, especially prior to bioanalytical approaches.
Keywords
UHPLCTHFMAALLEDVBTRIMMIPSPEEGDMACECLOQSBSEDADMSPDTOFPETASPMEBSADMSOMS/MSdiode array detectorbovine serum albuminethylene glycol dimethacrylateSolid-phase extractionLiquid–liquid extractionMolecularly imprinted solid-phase extractionMethacrylic acidCapillary electrochromatographyBioanalysissolid-phase microextractionTetrahydrofuranmatrix-assisted laser desorption/ionizationLOD یا Limit of detectiondivinyl benzeneDimethyl sulfoxideRamTime-of-Flight SorbentsMass spectrometryTandem mass spectrometryFluorescenceMatrix solid-phase dispersionMALDICSFCerebrospinal fluidMetaboliteslimit of quantificationlimit of detectionStir-bar sorptive extractionMISPErestricted access materialMolecularly imprinted polymersBiomarkersMEPsMolecularly imprinted polymerUltra High Performance Liquid Chromatography
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Mariana Roberto Gama, Carla Beatriz Grespan Bottoli,