Article ID Journal Published Year Pages File Type
5137712 Journal of Pharmaceutical and Biomedical Analysis 2018 38 Pages PDF
Abstract
Two analogs of sildenafil (compounds 1 and 2) were detected in three powder products acquired from online drug markets during an LC-UV-MS analysis of psychotropic drugs. Their structures were established by high-resolution mass spectrometry and NMR spectroscopy. Compound 1 was identified as 5-(5-(3,5-dimethylpiperazine-1-carbonothioyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-thione and named dimethyldithiodenafil. Compound 2 was identified as 5-(5-(3,5-dimethylpiperazine-1-carbonothioyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one and named dimethylthiocarbodenafil. Compound 1 was subjected to the phosphodiesterase assay (IC50 = 0.20 nM). The three powder products were found to contain 12-19 mg of dimethyldithiodenafil and 1.4-3.9 mg of dimethylthiocarbodenafil per tube.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Authors
, , , , , , , , ,