Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5137712 | Journal of Pharmaceutical and Biomedical Analysis | 2018 | 38 Pages |
Abstract
Two analogs of sildenafil (compounds 1 and 2) were detected in three powder products acquired from online drug markets during an LC-UV-MS analysis of psychotropic drugs. Their structures were established by high-resolution mass spectrometry and NMR spectroscopy. Compound 1 was identified as 5-(5-(3,5-dimethylpiperazine-1-carbonothioyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-thione and named dimethyldithiodenafil. Compound 2 was identified as 5-(5-(3,5-dimethylpiperazine-1-carbonothioyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one and named dimethylthiocarbodenafil. Compound 1 was subjected to the phosphodiesterase assay (IC50Â =Â 0.20Â nM). The three powder products were found to contain 12-19Â mg of dimethyldithiodenafil and 1.4-3.9Â mg of dimethylthiocarbodenafil per tube.
Keywords
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Miho Sakamoto, Jin Suzuki, Yuri Saito, Seiko Shimizu, Kazue Kobayashi, Machiko Nagashima, Takako Moriyasu, Haruhiko Fukaya, Koichi Saito,