| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5137723 | Journal of Pharmaceutical and Biomedical Analysis | 2017 | 22 Pages |
Abstract
The objective of this review is to give an overview of past, current and emerging trends in 2D-LC techniques applied to pharmaceutical compounds. The referenced studies cover the late 1980s to the present. Information regarding the different aspects of this analytical technique, including chromatographic conditions, instrumental setup and compounds of interest, was compiled and summarized into a synoptic table. Particular attention is paid to key features including (i) the interfaces used for coupling the two dimensions, (ii) the application fields, and (iii) the chromatographic modes that can be combined together. Finally an attempt is made to predict future advances in two-dimensional separation techniqes for pharmaceutical analysis.
Keywords
SECRPLCELSDNPLCIPCDADBMCAPIIEXMS/MSdiode array detectorSize-exclusion chromatographyCharged aerosol detectionMass spectrometry detectionElectrochemical detectionfluorescence detectionFluCADActive Pharmaceutical IngredientHILIChydrophilic interaction chromatographyIon-pair chromatographyNormal phase chromatographyReversed phase chromatographyliquid chromatographyIon exchange chromatographyBiopartitioning micellar chromatographyMicellar chromatography
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Marion Iguiniz, Sabine Heinisch,