| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5138054 | Journal of Pharmaceutical and Biomedical Analysis | 2017 | 9 Pages |
Abstract
UPLC-HRMS and 1H NMR platforms showed two different but complementary patterns of metabolites describing the changes ascribable to P. cuspidatum supplementation and using both approaches, a comprehensive resveratrol metabolism and urinary excretion could be observed. Markers of P. cuspidatum supplementation effects identified by UPLC-HRMS were mainly related to its antioxidant activity and to a possible “adaptogenic” activity. Urinary changes observed by 1H NMR were mainly related to energy metabolism. UPLC-HRMS and 1H NMR metabolomics approaches allowed the effects of a prolonged supplementation with P. cuspidatum on healthy rats to be observed. The statistical models built from both data sets showed metabolic changes in urines related to rat aging.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Gregorio Peron, Jalal Uddin, Matteo Stocchero, Stefano Mammi, Elisabetta Schievano, Stefano Dall'Acqua,