| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5138333 | Journal of Pharmaceutical and Biomedical Analysis | 2017 | 21 Pages |
Abstract
The method was validated for specificity, precision, linearity, accuracy, robustness and can be used in quality control during manufacture and for assessment of the stability samples of verapamil hydrochloride. To the best of our knowledge, a validated UPLC method which separates all the sixteen impurities disclosed in this investigation has not been published elsewhere. Total elution time was about 18Â min which allowed quantification of more than 100 samples per day. The analytical method discussed in British Pharmacopeia was pH sensitive and not compatible to LC-MS analysis but the method reported in this study is not involved any pH adjustment.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
S. Vijayabaskar, V. Mahalingam, Kalaivani Kalaivani,