Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5138769 | Journal of Trace Elements in Medicine and Biology | 2017 | 7 Pages |
Abstract
Pre-eclampsia is a hypertensive disorder that is associated with adverse maternal and perinatal outcomes. It has been proposed that specific trace and macro elements associated with antioxidant activities may also play a contributory role in aetiology of pre-eclampsia. The aim of this study was to measure the concentrations of thirteen different elements in hair and serum samples from women with a diagnosis of pre-eclampsia and compare them with normotensive controls. Venous blood and pubic hair samples were collected from forty-three pre-eclamptic and twenty-three normotensive pregnant women. In each sample, the concentration of arsenic (As); calcium (Ca); cadmium (Cd); chromium (Cr); cobalt (Co); magnesium (Mg); manganese (Mn); iron (Fe); copper (Cu); lead (Pb); selenium (Se); nickel (Ni); zinc (Zn) were measured using inductively coupled plasma-optical emission spectrometry. Cobalt concentration in hair was significantly lower in the pre-eclampsia group (1.56 ± 0.74 μg/g) compared to the normotensive group (2.89 ± 4.99 μg/g) (p = 0.02). The concentrations of Zn and Cr were significantly higher in hair samples from the pre-eclamptic group, compared to the normotensive control group (Zn, 395.99 ± 48.60 vs 330.88 ± 29.70 μg/g; Cr, 13.31 ± 2.67 vs 11.05 ± 7.62 μg/g: p â¤Â 0.05). There were no significant differences in the hair levels of other elements between groups. Serum Zn was significantly higher in the pre-eclamptic group (0.16-253.4 mg/L) compared to the normotensive group (0.2-48.4 mg/L) (p = 0.01). Serum Ca, Co, Cu, Mg, Mn and Se levels were found to be significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). This study confirms the association between pre-eclampsia and maternal trace as well as macro element levels.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
K. Maduray, J. Moodley, C. Soobramoney, R. Moodley, T. Naicker,