Article ID Journal Published Year Pages File Type
5138977 Microchemical Journal 2018 8 Pages PDF
Abstract
The urate concentration in oral fluid decreased with the increase of the stimulation and oral fluid flow rate (r = − 0.98, p = 0.01). Also, the lactate concentration was much (p = 0.03, two tailed) lower in samples collected under a mild stimulation (50 min− 1) than in samples collected without stimulation. Nevertheless, it progressively increased at higher stimulations (100 and 150 min− 1). A transfer process mediated by membrane carriers (i.e. urate transporter and organic anion transporters) was hypothesized to explain these results. Finally, a reduced variability (relative standard deviation below 10%) of the urate concentration was obtained when oral fluid was sampled at constant stimulation (70 min− 1), but it increased remarkably (20-50%) in case of sampling at self-selected pace. Nevertheless, expressing the salivary excretion of urate as a function of time (μg min− 1), the variability of sampling procedure at self-selected pace was lower than 15%.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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