| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5139530 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2018 | 9 Pages |
â¢Human serum albumin binding properties can be induced by modifications.â¢Glycation, oxidation and ageing are the most popular albumin modifications.â¢Modification of albumin influences on its physiological functions
Albumin, a major transporting protein in the blood, is the main target of modification that affects the binding of drugs to Sudlow's site I and II. These modification of serum protein moderates its physiological function, and works as a biomarker of some diseases. The main goal of the paper was to explain the possible alteration of human serum albumin binding properties induced by modifications such as glycation, oxidation and ageing, their origin, methods of evaluation and positive and negative meaning described by significant researchers.
Graphical AbstractDownload high-res image (117KB)Download full-size image
