Polyhedral oligomeric silsesquioxane-based hybrid monolithic columns: Recent advances in their preparation and their applications in capillary liquid chromatography

As a natural molecular-level organic-silica hybrid particle, polyhedral oligomeric silsesquioxane (POSS) is a good choice for the preparation of new hybrid monolithic columns because of its ease of fabrication, ultrahigh column efficiency, and excellent separation selectivity. In this review, we summarize the recently reported POSS-based hybrid monolithic columns, especially those reported in the recent 5 years. These POSS-based hybrid monolithic columns are classified according to the reactive groups of POSS and the introduced organically functionalized reagents, emphasizing the preparation methods and further applications in capillary liquid chromatography.