Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5141905 | Vibrational Spectroscopy | 2017 | 19 Pages |
Abstract
γ-Aminobutyric acid is a gamma-amino acid playing a fundamental role in the balance between neuronal excitation and inhibition in the mammalian central nervous system, being involved in several neuronal disorders. In this study, the monoclinic phase of γ-aminobutyric acid was investigated through Raman spectroscopy in the spectral range from 30 to 1700 cmâ1 for pressure between 1 atm and 7.1 GPa. A series of phase transitions at â¼0.1, 2.0 and 4.0 GPa was observed during the compression cycle. The modifications in the Raman spectra were interpreted mainly regarding the conformational changes of the molecules in the unit cell. In the phase transition at 4.0 GPa, modifications in the modes associated with both torsion and rocking of NH3+ were interpreted as a change in the hydrogen-bond network, beyond the conformational change itself. An analysis of sample integrity after the experiment aid to compare the degree of the conformational changes with those observed in phase transitions studied in some α-amino acid crystals.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
C.M. da Silva, J.G. Silva Filho, G.S. Pinheiro, R.C. Vilela, F.E.A. Melo, J.A. Jr., P.T.C. Freire,