Simultaneous estimation of dutasteride and tamsulosin hydrochloride in tablet dosage form by vierordt's method

Simple, rapid and accurate new vierordt's (VI) method or simultaneous equation (SE) method is developed and validated for the simultaneous estimation of dutasteride (DU) and tamsulosin hydrochloride (TA) in pure and pharmaceutical dosage form. The method is based on the measurement of absorbance at two wavelengths 240.6 nm and 279.4 nm, λmax of DU and TA in methanol respectively. Calibration curves are linear in the concentration ranges 20-40 μg/ml for DU and 16-32 μg/ml for TA. LOD, LOQ, precision and recovery studies are calculated. The proposed method is successfully applied for simultaneous estimation of DU and TA in pure and pharmaceutical dosage form.