Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5142408 | Arabian Journal of Chemistry | 2017 | 7 Pages |
Abstract
A sensitive, simple and rapid square-wave adsorptive stripping voltammetric method was developed and validated for the determination of Ribavirin in pharmaceutical formulations. The proposed method was based on the electrochemical reduction of Ribavirin at a hanging mercury drop electrode in Britton Robinson buffer at pH 10. A well-defined peak was observed at 880 mV with 30 s of accumulation time and 50 mV of accumulation potential. Under these optimized conditions, the square-wave adsorptive stripping voltammetric peak current showed a linear correlation on drug concentration over the range of 1 Ã 10â10-2 Ã 10â7 mol Lâ1 with a correlation coefficient of 0.9995 for the proposed method. The detection and quantitation limits for this method were 2.02 Ã 10â10 and 6.80 Ã 10â10 mol Lâ1, respectively. The results obtained for intra-day and inter-day precision (as RSD %) were between 0.447% and 1.024%. This method was applied successfully for the determination of Ribavirin in its pharmaceutical dosage forms with mean recoveries of 99.68 ± 0.13 with RSD % of 0.81% and 99.20 ± 0.24 with RSD % of 0.49% for two concentrations 5 Ã 10â9 and 5 Ã 10â8 mol Lâ1, respectively for 200 mg capsules. The results obtained from the developed square-wave adsorptive stripping voltammetric method were compared with those obtained by the analytical method reported in the literature.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Ahmed A. Abdel Gaber, Salwa A. Ahmed, Asmaa M. Abdel Rahim,