| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5142500 | Arabian Journal of Chemistry | 2016 | 6 Pages |
Abstract
In present study o-phenylenediamine and phenoxyacetic acid were used as starting material through series of steps 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]acetohydrazide 5 was obtained. Various derivatives of 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]-Nâ²-[(Z)-phenylmethylidene]acetohydrazide and some compounds containing oxadiazole bearing benzimidazole were synthesized by using various aromatic aldehyde, cyanogens bromide and carbon disulfide/potassium hydroxide. These were elucidated by IR, NMR and elemental analysis and their in vivo anticonvulsant screening was performed using MES and scPTZ. Two compounds 7g and j were found to be potent in both the screens and their protective index was found to be better than standard drugs used.
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Authors
Mohammad Shaharyar, Avijit Mazumder, Salahuddin Salahuddin, Ruchika Garg, Rishabh D Pandey,