Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5142505 | Arabian Journal of Chemistry | 2016 | 9 Pages |
Abstract
In this paper, we have described the conventional and microwave methods for the synthesis of 1-[2-(2-chloro-6-methyl(3-quinolyl))-5-(4-nitrophenyl)(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones (4a-l). Through this method, we have observed a decrease in reaction time and a better yield than the previously described conventional method. The application of microwave irradiation (MWI) is used for carrying out chemical transformations which were pollution free and eco-friendly. The structures of the compounds were characterized by IR, NMR and mass spectral data. These compounds (4a-l) were evaluated for their in vitro antimicrobial screening on different strains of bacteria and fungi. Among the compounds tested, compound 4h showed the highest activity.
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Authors
N.C. Desai, Amit M. Dodiya,