Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5142598 | Chemistry and Physics of Lipids | 2017 | 29 Pages |
Abstract
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that have been shown to regulate various physiological functions such as lipid metabolism and cholesterol homeostasis. Concordant reports have elicited the possibility to target them to cure many human diseases including arteriosclerosis, cancer, arthritis, and diabetes. The high relevance of modulating LXR activities to treat numerous skin diseases, mainly those with exacerbated inflammation processes, contrasts with the lack of approved therapeutic use. This review makes an assessment to sum up the findings regarding the physiological roles of LXRs in skin and help progress towards the therapeutic and safe management of their activities. It focuses on the possible pharmacological targeting of LXRs to cure or prevent selected skin diseases.
Keywords
IL1Acyclo-oxygenase-2Retinoid X receptorIL6VDRMITFLXRRXRDR4FLGIL1bTNFaPPARGABCG1MMPv-myc avian myelocytomatosis viral oncogene homologHMGCoAPharmacological targets3-hydroxy-3-methyl-glutaryl-coenzyme AABCA12IVLSLiMsLXRsTGM1Microsomal prostaglandin E synthaseLXREbeta-glucocerebrosidaseLXR response elementIL8ERKVEGFAiNOSCOX-2MCP-1Epigallocatechin-3-gallateEGCGNADPHCATABCA1MYCMDCTrpLPSGBAIfngLORapoapolipoproteinhydroxyeicosatetraenoic acidUltravioletOxysterolsInterleukin 1 alphainterleukin 1 betainterleukin 6Interleukin 8skin diseasestransglutaminase 1tumor necrosis factor ainducible nitric oxide synthaseVascular endothelial growth factor AfilaggrinLoricrinlipopolysaccharidematrix metallopeptidaseHETEmonocyte chemoattractant protein-1Catalaseliver X receptorMacrophage-derived chemokineextracellular signal-related kinaseInterferon gammainvolucrinPeroxisome proliferator activated receptor gamma
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Zangbéwendé Guy Ouedraogo, Allan Fouache, Amalia Trousson, Silvère Baron, Jean-Marc A. Lobaccaro,