Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5142612 | Chemistry and Physics of Lipids | 2017 | 9 Pages |
Abstract
Natural products are an interesting source of new therapeutics, especially for cancer therapy as 70% of them have botany origin. Propolis, a resinous mixture that honey bees collect and transform from tree buds, sap flows, or other botanical sources, has been used by ethnobotany and traditional practitioners as early in Egypt as 3000 BCE. Enriched in flavonoids, phenol acids and terpene derivatives, propolis has been widely used for its antibacterial, antifungal and anti-inflammatory properties. Even though it is a challenge to standardize propolis composition, chemical analyses have pointed out interesting molecules that also present anti-oxidant and anti-proliferative properties that are of interest in the field of anti-cancer therapy. This review describes the various geographical origins and compositions of propolis, and analyzes how the main compounds of propolis could modulate cell signaling. A focus is made on the putative use of propolis in prostate cancer.
Keywords
ribosomal protein S6 kinase beta-1IL1-βTLRp70S6KABCA1XIAPERKATP-binding cassette A1CAPEcIAP-2TNFαLXRsMMPDHT5α-DihydrotestosteroneNFκBu-PAcaffeic acid phenethyl esterinterleukin 1-βBaxtumor necrosis factor αToll-like receptorProstate cancerEthanolic extractsnuclear factor kappa-light-chain-enhancer of activated B cellsurokinase-type plasminogen activatorFlavonoidsTRAILMatrix metalloproteinasesBcl-2-associated X proteinX-linked Inhibitor of Apoptosis Proteinpropolisextracellular signal-regulated kinasesAndrogen ReceptorLiver X receptors
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Nada Zabaiou, Allan Fouache, Amalia Trousson, Silvère Baron, Amar Zellagui, Mesbah Lahouel, Jean-Marc A. Lobaccaro,