Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5142691 | Chemistry and Physics of Lipids | 2017 | 35 Pages |
Abstract
We used rimonabant to investigate the role of CB1 receptor on hepatic FFAs profile during NAFLD. Male mice C57BL/6 were divided into: control group fed with control diet 20 weeks (C; n = 6); group fed with HFD 20 weeks (HF; n = 6); group fed with control diet and treated with rimonabant after 18 weeks (R; n = 9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n = 10). Rimonabant (10 mg/kg) was administered daily to HFR and R group by oral gavage. Rimonabant decreased liver palmitic acid proportion in HFR group compared to HF group (p < 0.05). Liver stearic and oleic acid proportions were decreased in R group compared to control (p < 0.01 respectively). Rimonabant increased liver linoleic and arachidonic acid proportions in HFR group compared to HF group (p < 0.01 respectively). CB1 blockade may be useful in the treatment of HFD-induced NAFLD due to modulation of plasma lipid and hepatic FFA profile.
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Authors
Bojan JorgaÄeviÄ, Danijela VuÄeviÄ, Ivana ÄuriÄiÄ, SlaÄana Å obajiÄ, DuÅ¡an MladenoviÄ, Milena VeskoviÄ, Rada JeÅ¡iÄ VukiÄeviÄ, Tatjana RadosavljeviÄ,