Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5143234 | Current Opinion in Chemical Biology | 2017 | 10 Pages |
Abstract
Isoprenoids (terpenes/terpenoids) have many useful industrial applications, but are often not produced at industrially viable level in their natural sources. Synthetic biology approaches have been used extensively to reconstruct metabolic pathways in tractable microbial hosts such as yeast and re-engineer pathways and networks to increase yields. Here we review recent advances in this field, focusing on central carbon metabolism engineering to increase precursor supply, re-directing carbon flux for production of C10, C15, or C20 isoprenoids, and chemical decoration of high value diterpenoids (C20). We also overview other novel synthetic biology strategies that have potential utility in yeast isoprenoid pathway engineering. Finally, we address the question of what is required in the future to move the field forwards.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Claudia E Vickers, Thomas C Williams, Bingyin Peng, Joel Cherry,