Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5143428 | Current Opinion in Green and Sustainable Chemistry | 2017 | 8 Pages |
Abstract
The paper presents the most recent advances in applications of alternative medium to replace polar aprotic solvents such as dimethylformamide (DMF), dimethylacetamide (DMAc) or N-methyl-2-pyrrolidone (NMP). Focus is made on the use of nonionic designer surfactant (e.g. TPGS-750-M) in water instead of traditional organic solvents. Much attention is given to its applications to several commonly used transformations in active pharmaceutical ingredient (API) synthesis, such as amidation reactions, Suzuki-Miyaura cross-couplings, nitro group reductions, and aromatic nucleophilic substitutions. Case studies of successful uses to attain improved green processes are included. Future directions and most recent results using tailor-made reagents suitable for micellar environments are given.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Michael Parmentier, Christopher M. Gabriel, Pengfei Guo, Nicholas A. Isley, Jianguang Zhou, Fabrice Gallou,