Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5150853 | Coordination Chemistry Reviews | 2016 | 46 Pages |
Abstract
The clinical success of platinum-based chemotherapeutic agents was of enormous impact on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti-cancer drugs. During the last years, the research on cytotoxic transition metal (e.g. Ag, Au, Pt, Pd, Cu, Hg, Ru, Os, Rh and Ir) NHC complexes was successful and the results are remarkable. In this review, we provide an update on the recent advances in this direction, which reflects new discoveries since the publication of our previous review. The anti-tumor properties along with the mechanisms of action for these complexes as well as possible structure-activity relationships are discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Wukun Liu, Ronald Gust,