Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5150867 | Coordination Chemistry Reviews | 2016 | 52 Pages |
Abstract
Natural siderophores are generally not species-specific; they exhibit broad-spectrum activity and can be recognized by various types of microorganisms. Moreover, they generally miss proper sites for incorporating additional functionalities; e.g. fluorescent probes, surface-adhesive moieties or drug molecules, to be used for imaging and/or as therapeutic conjugates smuggled into microbial species via siderophore recognition and a 'Trojan Horse' strategy. Biomimetic analogues can overcome both these limitations and offer novel tools for both diagnostics and therapeutics. Siderophore mimics with a narrow spectrum of activity offer the possibility of developing selective diagnostic tools, while those with broad-spectrum activity may find therapeutic applications as antifungal drug delivery tools.
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Authors
Agnieszka Szebesczyk, Evgenia Olshvang, Abraham Shanzer, Peggy L. Carver, Elzbieta Gumienna-Kontecka,