Synthesis, characterization, DNA binding and cytotoxicity of fluoro-dipyrrin based arene ruthenium(II) complexes

Synthesis of four new arene ruthenium(II) complexes [(η6-C10H14)RuCl(MFPdpm)] (1); [(η6-C12H18)Ru-Cl(MFPdpm)] (2); [(η6-C10H14)RuCl(PFPdpm)] (3) and [(η6-C12H18)RuCl(PFPdpm)] (4) containing dipyrrin ligands 5-(4-fluoro)phenyldipyrromethene (MFPdpm) and 5-(penta-fluoro)phenyldipyrromethene (PFPdpm) have been described. DNA binding activities of 1-4 have been investigated by UV-Vis and fluorescence spectroscopy and their binding through the minor groove of DNA has been established by molecular docking studies. The complexes 1-4 exhibit significant cytotoxicity toward human lung cancer cell line (A549).140